منابع مشابه
Lynch syndrome and exposure to aristolochic acid in upper-tract urothelial carcinoma: its clinical impact?
The purpose of the current review was to describe the clinical risk for Lynch syndrome (LS) after exposure to aristolochic acid (AA) in cases of upper urinary-tract urothelial carcinoma (UTUC). A systematic review of the scientific literature was performed using the Medline database (National Library of Medicine, PubMed) using the following keywords: epidemiology, risk factor, AA, Balkan nephro...
متن کاملAssociation between Lynch syndrome and renal carcinoma.
We read with interest the study published by Ferrer et al. about a patient with Lynch syndrome (LS) who presented a colorectal carcinoma (CRC) and a synchronous clear cell renal carcinoma (CCRC) (1). From our point of view, it would be interesting to emphasize some aspects of this patient, such as the type of mutation carried by the patient, and its cancer familial tree. In addition, we would l...
متن کاملEffect of smoking on urothelial cancer risk in individuals with Lynch syndrome
Background Cigarette smoking is a well-described risk factor for a number of cancers and has been implicated as the most significant cause of urothelial cancer, conferring up to a 7-fold increased risk. Urothelial cancers are also part of the spectrum of cancers associated with Lynch syndrome. Several studies have looked at the impact of gene-environment interaction on cancer risk in Lynch synd...
متن کاملZKSCAN3 expression in urothelial carcinoma of the upper urinary tract and its impact on patient outcomes
We recently found that a zinc-finger transcription factor, ZKSCAN3, could induce the growth of bladder cancer cells. In this study, we immunohistochemically stained for ZKSCAN3 in upper urinary tract urothelial carcinoma (UUTUC) specimens. ZKSCAN3 was positive in 52 [42.4%; 26 (26.3%) weak (1+), 13 (13.1%) moderate (2+), and 3 (3.0%) strong (3+)] of 99 UUTUCs, which was significantly (P<0.001) ...
متن کاملRole of FGFR3 in Urothelial Carcinoma
Background and Objective: This study was undertaken to analyze the immunohistochemical expression of fibroblast growth factor receptor (FGFR3) in urothelial carcinoma and correlate its expression with the pathological stage, recurrence and other clinicopathological parameters. Material and Methods: A retrospective study was undertaken on paraffin blocks o...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22020531